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Updated: Jul 18, 2026

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
Published on: October 10, 2020
CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study
A Leichsenring1, R Losi-Guembarovski, M E Maciel
1Laboratório de Citogenética Humana e Oncogenética, Departamento de Genética, Universidade Federal do Paraná, 81531-970 Curitiba, PR, Brazil. eribeiro@ufpr.br
Genetic variations in CYP1A1 and GSTP1 enzymes do not appear to increase oral cancer risk. This study found no significant association between these specific gene polymorphisms and oral squamous cell carcinoma (OSCC) in the studied population.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- CYP1A1 and GSTP1 gene polymorphisms are linked to various cancers, including oral squamous cell carcinoma (OSCC).
- These genes encode enzymes crucial for metabolizing carcinogens from tobacco and alcohol, and their variants may alter enzymatic activity.
- The CYP1A1*2B allele may increase enzyme activity, leading to carcinogen accumulation, while the GSTP1*B variant might reduce catalytic activity, impairing carcinogen detoxification.
Purpose of the Study:
- To investigate the association between CYP1A1*2B and GSTP1*B allelic variants and the risk of developing oral squamous cell carcinoma (OSCC).
Main Methods:
- A case-control study was conducted with 72 OSCC cases and 60 matched healthy controls.
- Polymerase Chain Reaction (PCR) was used to identify CYP1A1*2B and GSTP1*B allelic variants.
- Controls were matched for age, gender, smoking habits, and ethnicity.
Main Results:
- No statistically significant association was found between the CYP1A1*2B variant and OSCC risk (OR = 1.06; 95% CI = 0.49-2.29).
- No statistically significant association was observed between the GSTP1*B variant and OSCC risk (OR = 1.40; 95% CI = 0.70-2.79).
Conclusions:
- The studied allelic and genotypic variants of CYP1A1*2B and GSTP1*B do not show a statistically significant association with oral squamous cell carcinoma (OSCC) in this population.
- Further research may be needed to explore other genetic factors or environmental interactions in OSCC development.
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