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Elevated urinary testosterone and androstanediol in precocious adrenarche.

Y Doberne, L S Levine, M I New

    Pediatric Research
    |October 1, 1975
    PubMed
    Summary
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    Precocious adrenarche in girls is linked to elevated urinary testosterone (T) and androstanediol (Adiol) levels. Hormone stimulation and suppression tests confirmed these elevated androgen levels in patients.

    Area of Science:

    • Endocrinology
    • Pediatric Endocrinology
    • Androgen Metabolism

    Background:

    • Precocious adrenarche is a condition characterized by early pubertal development.
    • Assessing androgen levels is crucial for understanding its pathophysiology.
    • Simultaneous measurement of testosterone and androstanediol offers a comprehensive hormonal profile.

    Purpose of the Study:

    • To evaluate urinary testosterone (T) and androstanediol (Adiol) levels in girls with precocious adrenarche.
    • To investigate the hormonal response to adrenocorticotropic hormone (ACTH) stimulation and dexamethasone suppression in these patients.

    Main Methods:

    • Development of a novel radioligand assay for simultaneous urinary T and Adiol determination.
    • Evaluation of nine girls with precocious adrenarche and 15 age-matched controls.

    Related Experiment Videos

  • Hormonal response assessment via ACTH infusion and dexamethasone administration in a subset of patients.

    • Main Results:

    • Girls with precocious adrenarche exhibited significantly elevated baseline urinary T and Adiol excretion compared to controls (P < 0.001).
    • ACTH stimulation resulted in a >50% increase in urinary T in all patients and a similar increase in Adiol in 4/5.
    • Dexamethasone administration led to a >25% decrease in urinary T in all patients and a comparable decrease in Adiol in 4/5.

    Conclusions:

    • Precocious adrenarche is associated with elevated androgen production, specifically testosterone and androstanediol.
    • The adrenal glands appear to be the primary source of the elevated androgens in these patients.
    • The developed radioligand method provides a valuable tool for diagnosing and monitoring precocious adrenarche.