Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone reconstruction with bone marrow stromal cells.

Wei Liu1, Lei Cui, Yilin Cao

  • 1Department of Plastic Surgery, Shanghai 9th People's Hospital, Shanghai, People's Republic of China.

Methods in Enzymology
|December 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repair of Defects in the Scalp and Face With Expanded Superficial Temporal Artery Flaps: A Single-Center Retrospective Study.

The Journal of craniofacial surgery·2021
Same author

[Effect of urease/nitrification inhibitor on urea nitrogen conversion in black soil and cinnamon soil.]

Ying yong sheng tai xue bao = The journal of applied ecology·2021
Same author

Artemisinin derivatives inhibit adipogenic differentiation of 3T3-L1 preadipocytes through upregulation of CHOP.

Biochemical and biophysical research communications·2021
Same author

<i>BRAF</i> <sup>V600E</sup> Mutation in Cell-Free DNA, Rather than in Lesion Tissues, at Diagnosis Is An Independent Prognostic Factor in Children with Langerhans Cell Histiocytosis.

Molecular cancer therapeutics·2021
Same author

Polymorphic membrane protein 20G: A promising diagnostic biomarker for specific detection of Chlamydia psittaci infection.

Microbial pathogenesis·2021
Same author

Assessment of Resistance to Cereal Cyst Nematode, Stripe Rust, and Powdery Mildew in Wheat-<i>Thinopyrum intermedium</i> Derivatives and Their Chromosome Composition.

Plant disease·2021
Same journal

1,2-Aminothiol-specific conjugation for dual-color fluorescent labeling via ultrafast TAMM conjugates.

Methods in enzymology·2026
Same journal

Nitrone dipoles in bioorthogonal chemistry applications.

Methods in enzymology·2026
Same journal

Bioorthogonal labeling of sialic acid isomers for detection of glycoconjugates by mass spectrometry imaging and microscopy.

Methods in enzymology·2026
Same journal

Bioorthogonal photocatalytic proximity labeling for quantitative mapping of cell-cell interactions.

Methods in enzymology·2026
Same journal

inCu-click: Enabling copper-catalyzed click chemistry inside living cells.

Methods in enzymology·2026
Same journal

Site-specific antibody labeling via endo-S2 mediated Fc glycan remodeling.

Methods in enzymology·2026
See all related articles

Bone marrow stromal/stem cells (BMSCs) show promise for bone regeneration. When combined with biodegradable scaffolds in large animal models, BMSCs facilitate effective bone repair, supporting therapeutic applications.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Bone marrow stromal/stem cells (BMSCs) are multipotent stem cells crucial for cell therapy and tissue engineering.
  • BMSCs exhibit significant osteogenic differentiation potential, confirmed in vitro and in small animal models.
  • Bone defects present a significant clinical challenge requiring advanced therapeutic solutions.

Purpose of the Study:

  • To evaluate the efficacy of BMSCs combined with biodegradable scaffolds for bone regeneration in large animal models.
  • To assess the potential of tissue-engineering approaches for bone repair, minimizing donor site morbidity.
  • To bridge the gap between experimental findings and clinical translation for engineered bone repair.

Main Methods:

  • In vivo studies utilizing large animal models were conducted.

Related Experiment Videos

  • Bone marrow stromal/stem cells were implanted with biodegradable scaffolds.
  • Bone formation and repair capabilities were assessed post-implantation.

    • Main Results:

    • The study demonstrated successful bone regeneration and repair using BMSCs and biodegradable scaffolds in vivo.
    • Results indicate the feasibility of this tissue-engineering approach for clinical application.
    • Large animal models confirmed the potential for therapeutic bone repair.

    Conclusions:

    • Bone regeneration and repair using BMSCs and biodegradable scaffolds is a realistic and achievable goal.
    • This approach offers a promising alternative to traditional bone grafting, avoiding donor site morbidity.
    • Further translation to clinical trials is supported by these in vivo findings in large animal models.