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Updated: Jun 27, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Published on: February 3, 2015

Nitrone dipoles in bioorthogonal chemistry applications

Elexa Scott1, Jason D Josephson1, Didier A Bilodeau1

  • 1Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, University of Ottawa, Ottawa, Ontario, Canada.

Methods in Enzymology
|June 25, 2026
PubMed
Summary

Bioorthogonal chemistry utilizes nitrones for faster, tunable molecular ligation. These alkyne-nitrone cycloadditions offer efficient bacterial labeling and orthogonal dual-labeling strategies.

Keywords:
BioorthogonalCuANCRDual strain-promoted chemistryKinugasa reactionLive-cell labelingSPANCnitrone

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