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Related Experiment Videos

The co-receptor function of CD4.

C A Janeway1

  • 1Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510.

Seminars in Immunology
|May 11, 1991
PubMed
Summary
This summary is machine-generated.

CD4 acts as a crucial co-receptor in T cell activation, significantly enhancing T cell receptor signaling. Its function ensures CD4 T cells primarily recognize peptides presented by MHC class II molecules.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • CD4 is an essential molecule in the T cell receptor complex.
  • It plays a role in T cell development, activation, and function.

Purpose of the Study:

  • To elucidate the co-receptor function of CD4 in T cell activation.
  • To understand how CD4 binding to MHC class II influences T cell signaling.

Main Methods:

  • Experimental systems demonstrating CD4's role, including cross-linking, T cell activation inhibition studies, and gene transfection.
  • Analysis of epitope interference phenomena.

Main Results:

  • CD4 binding to the peptide: self class II MHC complex potentiates T cell activation by 100-fold.

Related Experiment Videos

  • Evidence supports CD4's role as a co-receptor, transducing activating signals with the T cell receptor.

    • Conclusions:

    • CD4's co-receptor function is critical for effective T cell activation.
    • This function ensures specificity, directing CD4 T cells to recognize peptides presented by MHC class II molecules, not class I.