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Updated: Jul 18, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
Coagulation abnormalities in patients who have liver disease
1Division of Gastroenterology/Hepatology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B-154 Denver, CO 80262, USA. james.trotter@uchsc.edu
Abstract:
The liver plays a central role in the maintenance of normal hemostatic function. Because liver disease alters pathways of coagulation and anticoagulation, patients who have advanced disease can experience severe bleeding or thrombotic complications. Complications of advanced liver disease may also contribute to bleeding or thrombosis. This article reviews and discusses the management of the most common coagulation problems encountered in patients who have end-stage liver disease, which are thrombocytopenia and impaired humoral coagulation as measured by prolongation of the prothrombin time and international normalized ratio.
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