Genetic modification of cerebral arterial wall: implications for prevention and treatment of cerebral vasospasm
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Updated: Jul 18, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Anantha Vijay1, R Santhanam, Zvonimir S Katusic
1Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Abstract:
Genetic modification of cerebral vessels represents a promising and novel approach for prevention and/or treatment of various cerebral vascular disorders, including cerebral vasospasm. In this review, we focus on the current understanding of the use of gene transfer to the cerebral arteries for prevention and/or treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). We also discuss the recent developments in vascular therapeutics, involving the autologous use of progenitor cells for repair of damaged vessels, as well as a cell-based gene delivery approach for the prevention and treatment of cerebral vasospasm.
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