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Updated: Jul 18, 2026

Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics
Published on: April 17, 2017
Ultrafast excited state dynamics in protonated GWG and GYG tripeptides
G Grégoire1, C Dedonder-Lardeux, C Jouvet
1Laboratoire de Physique des Lasers, UMR7538 CNRS-Université Paris13, Institut Galilée, F-93430 Villetaneuse, France. gregoire@lpl.univ-paris13.fr
Abstract:
The excited state dynamics of two protonated tripeptides GWG and GYG has been investigated by pump/probe femtosecond measurements on photofragments, to explore the behavior of peptides where the terminal protonated amino group is not directly linked to the aromatic residue. The dynamics observed are short and surprisingly similar to the dynamics observed on the free protonated tryptophan and tyrosine aromatic amino acids. Specific photofragments observed for protonated GWG are related to the formation of a radical species WG degrees (+) after cleavage of the C(alpha)-N bond near the tryptophan residue.
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