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Related Experiment Videos

Comparison between pulsed and continuous radiofrequency delivery.

Ali Erdogan1, Eiko Walleck, Sebastian Rueckleben

  • 1Justus-Liebig-University of Giessen, Department of Cardiology/Angiology, 35392, Giessen, Germany. ali.erdogan@med.uni-giessen.de

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|December 14, 2006
PubMed
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Pulsed radiofrequency (RF) ablation is a faster and more reliable method for pulmonary vein (PV) isolation, creating more homogeneous lesions for atrial fibrillation treatment. This study demonstrated its feasibility and safety in animal models.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Pulmonary vein (PV) potentials are implicated as triggers for atrial fibrillation.
  • Percutaneous PV isolation is a key curative strategy for atrial fibrillation.
  • Optimizing lesion quality (homogeneity, transmurality) is crucial for effective PV isolation.

Purpose of the Study:

  • To assess the feasibility of ostial pulmonary vein isolation.
  • To compare continuous radiofrequency (RF) versus pulsed RF for lesion characteristics.
  • To evaluate lesion homogeneity and transmurality in PV isolation.

Main Methods:

  • In vivo study in seven pigs, targeting 28 pulmonary veins near the ostium.
  • Circumferential isolation using an octapolar ablation catheter.

Related Experiment Videos

  • Comparison of continuous RF (120s) versus pulsed RF (5ms duty cycle) energy delivery.
  • Lesion analysis included diameter, homogeneity, and transmurality assessment.

    • Main Results:

    • Pulsed RF produced significantly more homogeneous lesions in less time compared to continuous RF.
    • No significant differences were observed in electrode impedance or temperature.
    • No adverse events like tissue carbonization, popping, PV stenosis, or pericardial effusion occurred.

    Conclusions:

    • Ostial PV ablation using pulsed RF energy is feasible and effective.
    • Pulsed RF is a faster, more reliable method for creating homogeneous, transmural linear lesions.
    • The study found no increased risk of PV stenosis with pulsed RF ablation.