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Updated: Jul 18, 2026
08:44
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
Spectrum of illness in pediatric common variable immunodeficiency
Paul R Ogershok1, Mary Beth Hogan, Jon E Welch
1Section of Allergy and Immunology, Department of Pediatrics, West Virginia University School of Medicine, Morgantown, West Virginia 26506-9214, USA.
Summary
Common variable immunodeficiency (CVID) in children presents unpredictably with infections and low immunoglobulin levels. Associated conditions include asthma, autoimmune disorders, and growth deficiencies, complicating diagnosis.
Area of Science:
- Pediatric Immunology
- Clinical Allergy and Immunology
- Immunodeficiency Disorders
Background:
- Common variable immunodeficiency (CVID) typically manifests in adulthood.
- Pediatric CVID diagnosis is challenging due to varied presentations.
- Understanding pediatric CVID is crucial for early intervention.
Purpose of the Study:
- To investigate the clinical presentation of CVID in pediatric patients.
- To identify associated medical conditions in children with CVID.
- To improve diagnostic approaches for pediatric CVID.
Main Methods:
- Retrospective medical record review of pediatric CVID patients (1992-2005).
- Inclusion criteria: recurrent infections, low immunoglobulin levels (IgG, IgA, IgM), poor vaccine response, no other cause.
- Data collected on presentation, infections, and comorbidities.
Main Results:
- 12 pediatric CVID patients identified; mean age at presentation was 8 years.
- Common infections: sinusitis (75%), otitis media (67%), pneumonia (58%).
- Associated conditions: asthma (83%), autoimmune disorders, growth hormone deficiency, renal disease, and sarcoma.
Conclusions:
- Pediatric CVID diagnosis is difficult due to unpredictable symptoms.
- Asthma, autoimmune diseases, endocrine, renal, and oncologic conditions are associated with pediatric CVID.
- Early recognition of diverse CVID manifestations in children is essential.
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