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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

Updated: Jul 18, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

Quiz. Primary breast amyloidosis.

Alexandra Athanasiou1, Daniel Vanel, Gorana Tomasic

  • 1Department of Radiology, Institut de Cancérologie, Gustave-Roussy, 94805 Villejuif, France. alexandra.athanasiou@curie.net

European Journal of Radiology
|December 15, 2006
PubMed
Summary

Primary breast amyloidosis is a rare condition often presenting as breast masses on mammography. This case highlights its unusual presentation solely as suspicious microcalcifications, emphasizing the need for thorough diagnostic evaluation.

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Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

Area of Science:

  • Radiology
  • Pathology
  • Oncology

Background:

  • Primary breast amyloidosis is an uncommon condition.
  • It typically manifests as suspicious masses on mammography, potentially with microcalcifications.
  • Definitive diagnosis relies on histopathological examination.

Purpose of the Study:

  • To report an unusual case of primary breast amyloidosis.
  • To describe its presentation solely as suspicious microcalcifications on mammography.
  • To underscore the importance of considering rare diagnoses in breast imaging.

Main Methods:

  • Review of mammographic findings.
  • Histopathological analysis of biopsy samples.
  • Cytological examination of fine needle aspiration.

Main Results:

  • The case presented with clustered, suspicious microcalcifications as the sole mammographic finding.
  • No associated mass was detected on mammography.
  • Histopathology confirmed primary breast amyloidosis.

Conclusions:

  • Primary breast amyloidosis can present atypically, without a discernible mass.
  • Mammographic microcalcifications alone can be the primary manifestation.
  • Diagnostic workup should include biopsy for definitive diagnosis in equivocal cases.