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Published on: July 2, 2013
Reversible nonfluent aphasia and left frontal hypoperfusion during topiramate treatment
S F Cappa1, P Ortelli, V Garibotto
1Department of Neuroscience, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy. cappa.stefano@hsr.it
Abstract:
We report the case of a patient with complex partial seizures who developed a nonfluent aphasia when topiramate was added to his therapy. This emergent adverse effect appeared to be reversible, as language performance improved after discontinuation of topiramate. Interictal SPECT performed when the patient was aphasic revealed a focal perfusion reduction in the left lateral and mesial frontal cortex, which was no longer evident at a follow-up study after language recovery.
