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An Open-Source Normothermic Perfusion System Designed for Research Scientists

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Published on: July 18, 2025

Selected hypoxic stop-flow perfusions: indication and limits.

Stefano Guadagni¹, Evangelos Kanavos, Mario Schietroma

¹Department of Surgical Sciences, University of L'Aquila, L'Aquila, Italy. stefanoguadagni@interfree.it

|December 16, 2006

Summary

Hypoxic stop-flow perfusion offers a promising treatment for unresectable cancers, showing encouraging survival rates for rectal, pancreatic, and melanoma patients. Further research into tailored chemotherapy and hyperthermia could enhance its effectiveness.

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Area of Science:

Oncology
Surgical Oncology
Locoregional Chemotherapy

Background:

Unresectable cancers present a significant therapeutic challenge.
Stop-flow perfusion is a locoregional chemotherapy technique that temporarily blocks blood supply to the tumor area.
Hypoxic conditions may enhance chemotherapy efficacy.

Purpose of the Study:

To report clinical experience with hypoxic stop-flow perfusion.
To evaluate survival outcomes in patients treated with this method.
To discuss future research directions for this treatment modality.

Main Methods:

Over 500 hypoxic stop-flow perfusions were performed since December 1997.
Indications included recurrent rectal cancer, advanced pancreatic cancer, and recurrent pelvic/limb melanoma.
Data on patient survival was collected and analyzed.

Main Results:

Median survival for recurrent rectal cancer was 12.2 months.
Median survival for advanced pancreatic cancer was 9.6 months.
Median survival for recurrent pelvic and limb melanoma was 34.4 months, and for recurrent limb melanoma was 23.8 months.

Conclusions:

Hypoxic stop-flow perfusion demonstrates encouraging efficacy as a treatment for specific unresectable cancers.
The technique warrants consideration as a viable therapeutic option.
Future research should explore combinations with tailored chemotherapy and hyperthermia.