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Updated: Jul 18, 2026
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Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
Association between osteopontin and human abdominal aortic aneurysm
Jonathan Golledge1, Juanita Muller, Neil Shephard
1The Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Queensland, 4811 Australia. Jonathan.Golledge@jcu.edu.au
Arteriosclerosis, Thrombosis, and Vascular Biology
|December 16, 2006
Summary
Serum osteopontin (OPN) levels are linked to abdominal aortic aneurysm (AAA) presence and growth. However, OPN gene variations were not associated with AAA in this study.
Area of Science:
- Cardiovascular Research
- Biomarker Discovery
- Genetics
Background:
- Osteopontin (OPN) is implicated in aortic aneurysm pathogenesis.
- The role of OPN in human abdominal aortic aneurysm (AAA) requires further investigation.
Purpose of the Study:
- To investigate the association between serum OPN concentration and genetic variants with human AAA.
- To determine if OPN can serve as a biomarker for AAA presence and progression.
Main Methods:
- Examined OPN genotypes in 4227 subjects and measured aortic diameter and risk factors.
- Measured serum OPN concentrations using ELISA in two cohorts (665 subjects).
- Assessed OPN tissue concentration and predicted AAA growth over 3 years in 198 patients.
Main Results:
- Serum OPN concentration was independently associated with AAA presence.
- Higher serum OPN levels predicted AAA presence and growth.
- Increased OPN concentration in the aortic wall was observed in AAA patients compared to controls.
- No association was found between OPN gene variants and AAA or its expansion.
Conclusions:
- Serum and tissue OPN concentrations are associated with human AAA.
- OPN gene variations are not linked to AAA.
- OPN shows potential as a biomarker for AAA detection and monitoring.
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