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Related Experiment Video

Updated: Jul 18, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

[Allogenic meniscus transplantation].

Michael Dienst1, Dieter Kohn

  • 1Geschäftsführender Oberarzt, Universitätsklinik für Orthopädie und Orthopädische Chirurgie, Kirrberger Strasse, Gebäude 37, D-66421 Homburg/Saar, Germany. Michael_Dienst@yahoo.de

Operative Orthopadie Und Traumatologie
|December 16, 2006
PubMed
Summary

Total meniscus replacement in young patients with significant knee pain and dysfunction can restore function. This procedure shows a 70-80% transplant survival rate, improving joint function and reducing pain in suitable candidates.

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Area of Science:

  • Orthopedic surgery
  • Biomedical engineering
  • Sports medicine

Background:

  • Meniscal loss in young, active patients often leads to symptomatic early arthrosis.
  • Loss of the lateral or medial meniscus can cause pain, instability, and impaired joint function.

Purpose of the Study:

  • To evaluate the efficacy of total meniscus replacement for pain reduction and functional improvement.
  • To assess the long-term survival rate and outcomes of meniscal allograft transplantation.

Main Methods:

  • Allogenic meniscal transplant preparation and fixation via "horn ligaments" into tibial drill holes.
  • Arthrotomy, osteotomy of the femoral epicondyle, and meniscal residue excision.
  • Fixation using sutures to the outer rim/capsule and bone screws for horn ligaments.

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Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
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Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

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Last Updated: Jul 18, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Main Results:

  • A 70-80% transplant survival rate was observed at 3-7 years post-surgery.
  • Significant improvements in joint function and reduction in pain were reported.
  • Stable fixation of meniscal horns is biomechanically crucial for successful outcomes.

Conclusions:

  • Total meniscus replacement is effective for select indications, offering good pain relief and functional recovery.
  • Proper fixation of the meniscal horns is critical for long-term graft survival.
  • Simultaneous anterior cruciate ligament reconstruction and staged correction osteotomy are recommended.