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Updated: Jul 18, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

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Published on: February 24, 2014

Genome maintenance and mutagenesis in embryonic stem cells

Qing Lin1, Sarah L Donahue, H Earl Ruley

  • 1Department of Microbiology and Immunology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232-2363, USA.

Cell Cycle (Georgetown, Tex.)
|December 19, 2006
PubMed
Summary

Carcinogens can cause widespread loss of heterozygosity (LOH) in stem cells, suggesting LOH arises from genotoxic exposure rather than chromosomal instability. This finding is crucial for understanding nonhereditary cancers.

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Overview
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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