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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Related Experiment Video

Updated: Jul 18, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Erythrodermic lichen planus pemphigoides].

M Campos-Domínguez1, C Silvente, P de la Cueva

  • 1Servicio de Dermatología, Unidad de Enfermedades Ampollosas, Hospital General Universitario Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, Spain. miniacampos@gmail.com

Actas Dermo-Sifiliograficas
|December 19, 2006
PubMed
Summary

Lichen planus pemphigoides, a rare cause of erythroderma, presents with bullous lesions. This case highlights successful cyclosporine treatment for erythrodermic lichen planus pemphigoides.

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Area of Science:

  • Dermatology
  • Immunodermatology

Background:

  • Lichen planus is a rare cause of erythroderma.
  • Lichen planus pemphigoides is a subtype characterized by bullous lesions resembling bullous pemphigoid.

Observation:

  • A 49-year-old female presented with erythrodermic lichen planus pemphigoides.
  • The patient exhibited extensive skin redness and blistering.

Findings:

  • The patient showed a satisfactory response to cyclosporine treatment.
  • Diagnosis was confirmed through physical examination and immunofluorescence studies.

Implications:

  • Cyclosporine can be an effective treatment for erythrodermic lichen planus pemphigoides.
  • Immunofluorescence is crucial for diagnosing this rare condition.