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Polymer: bioceramic composites optimization by tetracycline addition.

André L Pataro1, Michele F Oliveira, Karina I R Teixeira

  • 1Departamento de Odontologia Restauradora da Faculdade de Odontologia da Universidade Federal de Minas Gerais (UFMG), Brazil.

International Journal of Pharmaceutics
|December 19, 2006
PubMed
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Adding tetracycline (TC) to poly-lactic acid polymer (PLA) and copolymer of lactic and glycolic acid (PLGA) composites improved biocompatibility. This optimized material demonstrated reduced inflammation and enhanced wound healing in vivo.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Drug Delivery Systems

Background:

  • Biocompatible composites are crucial for medical implants.
  • Poly-lactic acid polymer (PLA) and copolymer of lactic and glycolic acid (PLGA) are widely used biodegradable polymers.
  • Bioceramic matrices enhance bone regeneration and implant integration.

Purpose of the Study:

  • To evaluate the biocompatibility of PLA/PLGA composites dispersed in a bioceramic matrix (Osteosynt).
  • To assess the effect of tetracycline (TC) addition on the composite's biocompatibility and inflammatory response.
  • To investigate the in vitro and in vivo performance of the optimized composite material.

Main Methods:

  • In vitro biocompatibility testing using direct contact (ASTM F-813) and elution (USP-XXIII, ISO 10993-5) assays.

Related Experiment Videos

  • In vivo subcutaneous implantation in Swiss mice for macroscopic and histologic evaluation over 56 days.
  • Scanning Electron Microscopy (SEM) for observing tissue-material interactions like angiogenesis and cellular adsorption.

    • Main Results:

    • Tetracycline (TC) addition at 0.01% (w/w) did not impact in vitro composite cytotoxicity.
    • In vivo studies revealed an initial inflammatory infiltrate, with tissues normalizing by 21 days post-implantation.
    • TC significantly reduced inflammatory signs during the critical wound healing period (p<0.05).
    • SEM analysis confirmed angiogenesis, cellular adsorption, and fibrous deposit formation.

    Conclusions:

    • Tetracycline (TC) addition optimizes the biocompatibility of polymer/bioceramic composites.
    • The composite material demonstrates a beneficial anti-inflammatory response during early wound healing.
    • This optimized composite holds potential for applications requiring enhanced tissue integration and reduced inflammation.