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Related Experiment Video

Updated: Aug 10, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Cryptic Oral Microbiota: What Is Its Role as Obstructive Sleep Apnea-Related Periodontal Pathogens?

Mayra A Téllez Corral^1,2,3, Eddy Herrera Daza⁴, Hayde K Cuervo Jimenez²

¹Centro de Investigaciones Odontológicas, Facultad de Odontología, Pontificia Universidad Javeriana, Bogotá D.C. 110231, Colombia.

International Journal of Environmental Research and Public Health

|February 11, 2023

Summary

Cryptic oral microorganisms, rarely considered pathogens, may drive periodontitis and obstructive sleep apnea (OSA). These microbes contribute to dysbiotic oral microbiota, potentially increasing chronic disease risk.

Keywords:

MALDI-TOF chronic diseases obstructive sleep apnea oral microbiota pathogenic microbiota periodontitis

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Area of Science:

Oral microbiology
Periodontology
Sleep medicine

Background:

Periodontitis is linked to known pathogens, but the role of
cryptic microorganisms
remains unclear.
These rarely studied microbes may influence oral health and disease.
Obstructive sleep apnea (OSA) shares risk factors with periodontitis.

Purpose of the Study:

To investigate the presence and correlation of cultivable cryptic oral microorganisms.
To determine the potential role of these microbes in periodontitis and OSA.

Main Methods:

Analysis of oral samples from 75 participants with or without periodontitis and/or OSA.
Identification of cultivable cryptic oral microorganisms using MALDI-TOF.
Statistical analysis of microbial frequencies, clusters, and correlations.

Main Results:

Dental-biofilm-induced gingivitis and stage III periodontitis showed the highest cryptic microorganism diversity.
Specific genera were associated with disease conditions, while others were linked to health.
Certain species may be linked to periodontitis and OSA comorbidities.

Conclusions:

Cryptic microorganisms in periodontitis and OSA patients act as potential pathogens.
These microbes promote dysbiotic microbiota and chronic disease development.
Further research is needed to understand the function of these oral pathogens.