Related Experiment Videos
Relationship of cardiovascular risk factors and serum ferritin with C-reactive protein
Ki Chul Sung1, Jin Ho Kang, Hun Sub Shin
1Division of Cardiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. kcmd.sung@samsung.com
Insights
Serum ferritin correlates with elevated C-reactive protein (CRP) in individuals with high LDL cholesterol, suggesting a link to cardiovascular disease risk. Further research is needed to explore interventions targeting ferritin and CRP levels.
Area of Science:
- Cardiovascular Science
- Biochemistry
- Clinical Medicine
Background:
- Serum iron influences low-density lipoprotein (LDL) cholesterol oxidation and inflammation, positively correlating with coronary heart disease.
- Elevated C-reactive protein (CRP), an inflammatory marker, is a risk factor for cardiac events.
Purpose of the Study:
- To investigate the association between cardiovascular disease risk factors, serum ferritin, and CRP levels.
Main Methods:
- Study involved 808 participants (465 males, 343 females).
- Elevated levels defined as CRP >3.0 mg/L, serum ferritin >200 ng/mL, total cholesterol >200 mg/dL, LDL-cholesterol >160 mg/dL.
- Low levels defined as high-density lipoprotein cholesterol <40 mg/dL.
Main Results:
- No correlation between serum ferritin and hsCRP in subjects with low LDL-cholesterol (OR = 1.68, p = 0.144).
- A significant correlation was found between serum ferritin and hsCRP in subjects with elevated LDL-cholesterol (OR = 11.21, p = 0.032).
- Interaction term analysis confirmed a strong correlation between hsCRP and serum ferritin in elevated LDL-cholesterol group (p = 0.002).
Conclusions:
- Serum ferritin's role in LDL-cholesterol oxidation may contribute to inflammation and elevated hsCRP.
- Prospective studies are warranted to evaluate the efficacy of reducing serum ferritin and CRP levels through interventions for cardiovascular disease prevention.
Background:
Serum iron plays an important role in the oxidation of low-density lipoprotein (LDL) cholesterol, it induces inflammatory reactions and it is positively related to coronary heart disease. An increase of the inflammatory marker, C-reactive protein (CRP), is a risk factor for future cardiac events. Hence, we examined the association of the cardiovascular disease risk factors and serum ferritin with CRP.
Methods:
This study was performed on 808 subjects (465 males and 343 females). CRP levels >3.0 mg/L, serum ferritin levels >200 ng/mL, total cholesterol levels >200 mg/dL and LDL-cholesterol levels >160 mg/dL were all considered as elevated. High-density lipoprotein cholesterol levels <40 mg/dL were considered as low.
Results:
In the group with low LDL-cholesterol, no correlation was detected between serum ferritin and hsCRP [odds ratio (OR) = 1.68, 95% confidence interval (CI) = 0.81-3.48, p = 0.144]. However, a correlation was detected in the group with elevated LDL-cholesterol (OR = 11.21, 95% CI = 1.14-110.27, p = 0.032). In addition, when the interaction term was added to the assessment of the correlation between the elevated hsCRP and LDL-cholesterol, the strong correlation of hsCRP and serum ferritin was confirmed (p = 0.002).
Conclusions:
Oxidation of LDL-cholesterol by serum ferritin may play a role in the inflammatory reaction and for the increased hsCRP. Future prospective studies may be required to assess whether reducing the serum ferritin and CRP levels via medical intervention and life style modification would be helpful for preventing cardiovascular disease.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:30Coronary Artery Disease I: Introduction
01:12Relative Risk