A novel HLA-A*11 allele, A*1118, identified by sequence-based typing

Area of Science:

• Immunogenetics
• Molecular Biology

Background:

• Human Leukocyte Antigen (HLA) alleles are crucial for immune response.
• The accurate identification and characterization of novel HLA alleles are essential for transplantation and disease association studies.

Purpose of the Study:

• To report the discovery and initial characterization of a novel HLA-A allele, designated A*1118.
• To detail the genetic and protein sequence differences between A*1118 and a closely related known allele.

Main Methods:

• High-resolution sequence-based typing was employed for allele identification.
• Nucleotide sequence analysis was performed to identify differences between alleles.
• Amino acid sequence translations were analyzed to determine resulting protein changes.

Main Results:

• A novel Human Leukocyte Antigen (HLA) allele, A*1118, was identified.
• A*1118 differs from A*110101 by three nucleotide substitutions.
• These nucleotide changes result in three amino acid alterations at positions 70, 74, and 90 in the mature protein.

Conclusions:

• The novel allele A*1118 represents a distinct genetic entity within the HLA-A locus.
• The identified amino acid changes may have implications for T-cell recognition and immune function.
• This finding expands the known repertoire of HLA-A alleles and contributes to immunogenetic databases.