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[Advances in pathogenesis of psoriasis]
1Department of Dermatology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Summary
Transgenic mouse models illuminate psoriasis pathogenesis, revealing key roles for vascular endothelial growth factor (VEGF), signal transducer and activator of transcription 3 (Stat3), and c-Jun/JunB genes in disease development and potential therapeutic targets.
Area of Science:
- Dermatology and immunology
- Genetics and molecular biology
- Animal models of human disease
Context:
- Psoriasis pathogenesis understanding has advanced significantly with the development of genetically engineered mouse models.
- These models replicate key cellular and molecular aspects of human psoriasis, aiding research into disease mechanisms.
Purpose:
- To summarize recent advancements in understanding psoriasis pathogenesis through the use of novel transgenic mouse models.
- To highlight the roles of specific genes and pathways (VEGF, Stat3, c-Jun/JunB) in psoriasis-like phenotypes observed in mice.
Summary:
- K14-VEGF transgenic mice exhibit psoriasis features like dermal angiogenesis and altered epidermal dynamics.
- K5.Stat3C mice develop psoriasis-like skin conditions, suggesting Stat3's role in linking keratinocyte and immunocyte activation.
- Epidermal-specific c-Jun and JunB double-knockout mice show psoriasis-like skin and arthritic lesions.
Impact:
- These mouse models offer profound insights into the complex pathogenesis of psoriasis.
- The findings pave the way for developing more targeted and effective psoriasis therapies.
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