Related Experiment Video

Updated: Jul 18, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

The multiple roles of Id-1 in cancer progression

Ming-Tat Ling1, Xianghong Wang, Xiaomeng Zhang

  • 1Cancer Biology Group, Department of Anatomy, The University of Hong Kong, Hong Kong, China.

Differentiation; Research in Biological Diversity
|December 21, 2006
PubMed

Insights

Inhibitor of differentiation/DNA binding (Id-1) protein promotes cancer growth and survival. Overexpressed Id-1 drives tumor progression by activating pathways involved in invasion, angiogenesis, and resistance to chemotherapy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Id-1 (Inhibitor of differentiation/DNA binding) is a helix-loop-helix protein found in proliferating cells.
  • Id-1 regulates gene transcription by inhibiting basic helix-loop-helix transcription factors.
  • While initially recognized for its role in cellular differentiation, Id-1 is now known for its oncogenic functions.

Purpose of the Study:

  • To review recent evidence on the role of Id-1 in tumor progression.
  • To discuss the molecular mechanisms by which Id-1 promotes cancer development.

Main Methods:

  • Literature review of studies investigating Id-1 expression and function in various cancers.
  • Analysis of Id-1's involvement in key signaling pathways related to tumorigenesis.

Main Results:

  • Id-1 overexpression is frequent in over 20 cancer types, correlating with tumorigenesis.
  • Id-1 promotes cancer cell growth, survival, invasion (e.g., via MT1-MMP in breast cancer), and angiogenesis.
  • Id-1 activates pathways like EGF-R and NF-kappaB, leading to prostate cancer progression and androgen independence.
  • Id-1 confers resistance to chemotherapy-induced apoptosis in nasopharyngeal and prostate cancers via Raf-1/MAPK and JNK pathways.

Conclusions:

  • Id-1 plays a significant role in multiple stages of tumor progression.
  • Id-1's ability to modulate key signaling pathways highlights its potential as a therapeutic target in cancer.

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...