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Related Experiment Videos

Carboxypeptidase E in the mouse placenta.

Umashankar Singh1, Yang Yu, Elena Kalinina

  • 1Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, 75236 Uppsala, Sweden.

Differentiation; Research in Biological Diversity
|December 21, 2006
PubMed
Summary

Carboxypeptidase E (CPE) plays a crucial role in placental development. Its absence in mice leads to placental abnormalities, suggesting CPE and Carboxypeptidase D (CPD) involvement in interspecies hybrid placental dysplasia.

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Area of Science:

  • Reproductive biology
  • Developmental biology
  • Genetics

Background:

  • Carboxypeptidase E (CPE) is vital for processing endocrine pro-peptides, impacting metabolic and reproductive functions.
  • Down-regulation of CPE in abnormal placentas of interspecific hybrids suggests its role in placental development.
  • CPE and Carboxypeptidase D (CPD) share similar functions in peptide processing.

Purpose of the Study:

  • To investigate the role of Carboxypeptidase E (CPE) in murine placentation.
  • To analyze the placental phenotype of Cpe mutant mice.
  • To explore the involvement of CPE and CPD in interspecies hybrid placental dysplasia (IHPD).

Main Methods:

  • Determining CPE expression during murine gestation.
  • Phenotypic analysis of Cpe mutant placentas.

Related Experiment Videos

  • Microarray-based transcriptional profiling of Cpe mutant placentas.
  • Assessing co-localization of CPE and CPD in placental tissues.

    • Main Results:

    • CPE and CPD are co-localized in the mouse placenta from late mid-gestation to term.
    • Absence of CPE results in a placental phenotype with increased giant and glycogen cells and giant cell hypertrophy.
    • Transcriptional profiling revealed minimal gene expression changes in Cpe mutant placentas, with Dtprp being notably altered.
    • CPE and CPD deregulation precedes IHPD phenotype in interspecies hybrids.

    Conclusions:

    • CPE is essential for normal murine placental development.
    • CPE and CPD are causally implicated in interspecies hybrid placental dysplasia (IHPD).
    • CPE and CPD may function as speciation genes within the genus Mus.