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Updated: Jul 18, 2026

Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
Published on: January 22, 2020
Convenient method for monitoring Abeta aggregation by quartz-crystal microbalance
Hiroaki Okuno1, Kanae Mori, Tomofumi Jitsukawa
1Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1 Funabashi, Chiba 274-8510, Japan. okuno@phar.toho-u.ac.jp
Abstract:
We have found that a quartz-crystal microbalance is a facile and useful tool for detecting the specific aggregation of the amyloid-beta peptides responsible for Alzheimer's disease. This method greatly reduces the time and samples (corresponds to 1 Hz frequency decrease per 30 pg mass increase on a 4.9 mm(2) electrode) that are needed in the aggregation assay, and is also applicable to molecular interactions between smaller amyloid-beta fragment peptides such as the pentapeptide KLVFF.
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