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Paroxysmal nonepileptic events of childhood
1School of Medicine, The University of Connecticut, Farmington, CT 06106, USA. fdimari@ccmckids.org
Insights
Childhood paroxysmal nonepileptic events mimic seizures, posing diagnostic challenges. Accurate categorization relies on detailed history and careful observation for effective management.
Area of Science:
- Pediatric Neurology
- Clinical Diagnostics
- Epileptology
Background:
- Paroxysmal nonepileptic events (PNES) in children are common and often mimic epileptic seizures.
- These events present significant diagnostic challenges for clinicians, spanning neonates to young adults.
Purpose of the Study:
- To provide a clear categorization and clinical approach for childhood paroxysmal nonepileptic events.
- To aid clinicians in differentiating PNES from true epileptic seizures.
Main Methods:
- Detailed historical analysis of patient events.
- Careful clinical observation during episodes.
- Categorization based on altered mental status and sleep association.
Main Results:
- Clinical experience and detailed event descriptions are crucial for correct categorization.
- A simplified division of events based on mental status and sleep is proposed.
- Common diagnostic principles are effective despite the variety of entities.
Conclusions:
- Accurate diagnosis of PNES in children requires a thorough history and observation.
- Understanding the spectrum of PNES aids in appropriate clinical management.
- Effective strategies exist for identifying and managing these challenging pediatric events.
Abstract:
The paroxysmal nonepileptic events of childhood are a group of disorders, syndromes, and phenomena that mimic true epileptic seizures. Clinical experience and a clear description of the event in question will usually lead to a correct categorization. They span in age from neonate to young adult and are apt to be the most common diagnostic challenges clinicians face regularly. The key to diagnosis is a detailed history and careful observation. Despite the large number of discrete entities enumerated herein, common principles in clinical approach are successful and described. Each entity can pose a significant clinical challenge in identification, etiologic pathophysiology, genetics, and management. A simple division is offered here separating those episodes that are associated with an altered mental status or occurring during sleep and those without an altered mental status or occurring while awake.
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