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Menaka Rajapakse1, Guang Lan Zhang, Kellathur N Srinivasan

  • 1Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore, Singapore, 119613.

Autoimmunity
|December 21, 2006
PubMed

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...