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Updated: Jul 12, 2026
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Estimation of population heterozygosity and library construction-induced mutation rate from expressed sequence tag
A D Long1, P Beldade, S J Macdonald
1Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA. tdlong@uci.edu
Genetics
|December 21, 2006
Abstract:
Unigene alignments obtained from cDNA libraries made using multiple individuals are not currently used to estimate population heterozygosity, as they are known to harbor mutations created during library construction. We describe an estimator of population heterozygosity that utilizes only SNPs unlikely to be library construction artifacts.
