Efficacy of two triple eradication regimens in children with Helicobacter pylori infection

Area of Science:

• Pediatric Gastroenterology
• Infectious Diseases
• Microbiology

Background:

• Helicobacter pylori infection is a significant global health concern in children.
• Triple therapy regimens are standard for H. pylori eradication.
• Comparing the efficacy of different triple therapies in pediatric populations is crucial for optimizing treatment strategies.

Purpose of the Study:

• To compare the efficacy of two common triple therapy regimens for H. pylori eradication in children.
• To evaluate the effectiveness of bismuth subsalicylate, amoxicillin, metronidazole (BAM) versus omeprazole, amoxicillin, clarithromycin (OAC) in a pediatric cohort.

Main Methods:

• Retrospective analysis of 233 children diagnosed with H. pylori infection.
• Patients were treated with either OAC (n=141) or BAM (n=92) as first-line therapy.
• Eradication rates were assessed post-treatment for both regimens.

Main Results:

• The BAM regimen achieved an 85% eradication rate, while the OAC regimen achieved 74%.
• No statistically significant difference was observed between the eradication rates of BAM and OAC therapies.
• The BAM regimen demonstrated a trend towards higher efficacy in this Korean pediatric population.

Conclusions:

• Both BAM and OAC triple therapies are effective for H. pylori eradication in children.
• The BAM regimen may be more effective as a first-line treatment in Korean children, although statistical significance was not reached.
• Further research may be warranted to confirm the superiority of BAM in specific pediatric populations.