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Updated: Jul 18, 2026
08:49
Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
Published on: March 18, 2020
T cell-directed therapies: lessons learned and future prospects
Eric H Liu1, Richard M Siegel, David M Harlan
1Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Nature Immunology
|December 21, 2006
Summary
Agents targeting T cell function are crucial for autoimmune diseases and transplants. This review covers current, new, and investigational T cell therapies, discussing their clinical risks and benefits.
Area of Science:
- Immunology
- Pharmacology
- Transplantation
Background:
- T cell-targeting agents are foundational in treating autoimmune diseases and organ transplant rejection.
- Advances in T cell biology have significantly informed the development of these therapies.
- Current therapeutic strategies rely heavily on modulating T cell activity.
Purpose of the Study:
- To review existing, recently approved, and investigational T cell-specific agents.
- To analyze the clinical risks and benefits associated with these immunomodulatory therapies.
- To provide examples of successful and unsuccessful clinical applications of T cell-targeting drugs.
Main Methods:
- Literature review of T cell-specific agents in clinical and preclinical development.
- Analysis of clinical trial data and published outcomes for immunomodulatory drugs.
- Comparative assessment of therapeutic efficacy and safety profiles.
Main Results:
- Identified a range of T cell-modulating agents currently in use and under investigation.
- Highlighted the evolving landscape of immunotherapies for autoimmune conditions and transplantation.
- Documented instances where clinical translation of T cell agents succeeded and where it faced challenges.
Conclusions:
- The development of T cell-specific agents continues to advance, offering new hope for complex diseases.
- Careful evaluation of risks versus benefits is paramount for the clinical success of these potent immunomodulators.
- Ongoing research is crucial for optimizing T cell-based therapies and expanding their therapeutic applications.
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