Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient Experience and Caregiver Involvement in COVID-19 Care Pathways: Revealing System Blind Spots Through a Life-Events Calendar Approach.

Healthcare (Basel, Switzerland)·2026
Same author

A non-monotonic code for event probability in the human brain.

Nature communications·2025
Same author

Post-COVID syndrome in symptomatic COVID-19 patients: a retrospective cohort study.

BMC infectious diseases·2025
Same author

Retraction notice to "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial" [International Journal of Antimicrobial Agents 56 (2020), 105949].

International journal of antimicrobial agents·2024
Same author

Author Correction: Prevalence and risk factors for lung involvement on low-dose chest CT (LDCT) in a paucisymptomatic population of 247 patients affected by COVID-19.

Insights into imaging·2024
Same author

Two Determinants of Dynamic Adaptive Learning for Magnitudes and Probabilities.

Open mind : discoveries in cognitive science·2024

Related Experiment Video

Updated: Jul 18, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

How to fight antimicrobial resistance.

Cédric Foucault1, Philippe Brouqui

  • 1Service des Maladies Infectieuses et Tropicales, Hôpital Nord, Marseille, France.

FEMS Immunology and Medical Microbiology
|December 22, 2006
PubMed
Summary

Antimicrobial misuse fuels resistance and superbugs, increasing mortality. Multifaceted interventions and monitoring are key to controlling antimicrobial resistance, but require reinforcement beyond guidelines alone.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Antimicrobial misuse is a significant driver of antimicrobial resistance (AMR) and the emergence of superbugs.
  • Increasing AMR rates over recent decades have led to higher mortality and healthcare costs globally.
  • Existing control efforts, including guidelines, have shown limited success in curbing the rise of resistance.

Purpose of the Study:

  • To evaluate the effectiveness of various strategies in controlling antimicrobial resistance.
  • To identify the most efficient methods for combating the growing threat of superbugs.
  • To assess the impact of guidelines, educational programs, and combination therapy on AMR.

Main Methods:

  • Review and evaluation of existing local, regional, and national guidelines for antimicrobial resistance control.

More Related Videos

Enhanced Extraction of Low-Molecular Weight DNA from Wastewater for Comprehensive Assessment of Antimicrobial Resistance
06:54

Enhanced Extraction of Low-Molecular Weight DNA from Wastewater for Comprehensive Assessment of Antimicrobial Resistance

Published on: July 19, 2024

Related Experiment Videos

Last Updated: Jul 18, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Enhanced Extraction of Low-Molecular Weight DNA from Wastewater for Comprehensive Assessment of Antimicrobial Resistance
06:54

Enhanced Extraction of Low-Molecular Weight DNA from Wastewater for Comprehensive Assessment of Antimicrobial Resistance

Published on: July 19, 2024

  • Analysis of the impact of multifaceted intervention programs.
  • Assessment of the role of bacterial resistance and antibiotic use monitoring.
  • Evaluation of educational programs and antibiotic rotation policies.
  • Review of combination antimicrobial therapy efficacy.
  • Main Results:

    • Multifaceted interventions demonstrate the highest efficiency in controlling antimicrobial resistance.
    • Homogenized methodologies for monitoring bacterial resistance and antibiotic use are essential.
    • Guidelines and infection control measures alone are insufficient and require supplementary actions.
    • Educational programs and rotation policies lack sufficient evaluation in the literature.
    • Combination antimicrobial therapy has proven inefficient in controlling antimicrobial resistance.

    Conclusions:

    • A comprehensive, multifaceted approach is crucial for effective antimicrobial resistance control.
    • Continuous monitoring of resistance patterns and antibiotic consumption is vital.
    • Reinforcing guidelines with associated measures, alongside education and policy adjustments, is necessary.
    • Further research is needed to evaluate the impact of educational initiatives and rotation policies.