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Updated: Jun 12, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
Published on: November 12, 2012
Gene-environment interdependence
1Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK. j.wickham@iop.kcl.ac.uk
Abstract:
Behavioural genetics was initially concerned with partitioning population variance into that due to genetics and that due to environmental influences. The implication was that the two were separate and it was assumed that gene-environment interactions were usually of so little importance that they could safely be ignored. Theoretical considerations suggested that that was unlikely to be true and empirical findings are now accumulating on the demonstrated and replicated biological interactions between identified common single genetic variants and the operation of environmentally mediated risks. The paper outlines the evidence and considers why it is changing concepts in ways that matter.
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