Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electron radiotherapy: a study on dosimetric uncertainty using small cutouts.

James C L Chow1, Grigor N Grigorov

  • 1Department of Radiation Oncology, University of Toronto and Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

Physics in Medicine and Biology
|December 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence in radiation treatment planning: a narrative review from automation to clinical decision support.

Translational cancer research·2026
Same author

Correction: Editorial: National Cancer Research Month 2025: Advances in Detection, Treatment and Therapies in Oncology.

Frontiers in oncology·2026
Same author

Beyond TG‑43: A PRISMA-based systematic review on model-based dose-calculation algorithms in brachytherapy.

Journal of applied clinical medical physics·2026
Same author

Editorial: National Cancer Research Month 2025: Advances in Detection, Treatment and Therapies in Oncology.

Frontiers in oncology·2026
Same author

Machine learning in cancer imaging for enhanced precision in diagnosis and therapy.

Discover computing·2026
Same author

From standard to stratified: Modeling NTCP and EAR to personalize daily MV-CBCT in radiotherapy.

Journal of applied clinical medical physics·2025

Positional errors in electron radiotherapy cutouts can significantly alter dose delivery, especially with higher energy beams. Careful alignment is crucial to maintain treatment accuracy and avoid dosimetric uncertainties.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Dosimetry

Background:

  • Electron radiotherapy utilizes cutouts to shape the radiation beam.
  • Positional accuracy of these cutouts is critical for precise dose delivery.
  • Uncertainties in cutout placement can lead to significant dosimetric errors.

Purpose of the Study:

  • To investigate dosimetric uncertainties caused by positional errors of small cutouts relative to the central beam axis (CAX) in electron radiotherapy.
  • To quantify the impact of off-axis shifts on key dosimetric parameters at different electron beam energies.

Main Methods:

  • Measurements of percent depth doses, beam profiles, and output factors using 4, 9, and 16 MeV electron beams.
  • Monte Carlo simulations (EGSnrc system) to calculate 2D isodose distributions.

Related Experiment Videos

  • Systematic shifting of circular cutouts (4 cm diameter) from 0 to 10 mm off the machine CAX.

    • Main Results:

    • At 4 MeV, minimal changes (<0.1 mm) in d(m), R(80), and R(90) were observed with off-axis shifts.
    • At 9 and 16 MeV, d(m) decreased by 0.45 and 1.63 mm/mm respectively with off-axis shifts <6 mm.
    • R(80) and R(90) decreased by over 0.3 mm/mm off-axis shift for 9 and 16 MeV beams.
    • Isodose coverage along the in-line axis was reduced with increasing off-axis shift.

    Conclusions:

    • Positional uncertainties of small cutouts introduce significant dosimetric changes, particularly with higher energy electron beams.
    • Oncology staff must be aware of these dosimetric effects, especially when using high-energy beams with small cutouts.
    • Precise centering of cutouts is essential to mitigate treatment inaccuracies in clinical electron radiotherapy.