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Primary amyloidosis presenting as intrahepatic cholestasis
Sanjay K Bandyopadhyay1, Ranjana Bandyopadhyay, Anita Dutta
1Department of Medicine, Nil Ratan Sircar Medical College, Kolkata. drsanjay_b@rediffmail.com
Indian Journal of Pathology & Microbiology
|December 23, 2006
Summary
Primary amyloidosis can affect the liver, often without obvious symptoms. This case highlights intrahepatic cholestasis as a presentation, confirmed by liver biopsy and linked to a monoclonal light chain disorder.
Area of Science:
- Hepatology
- Oncology
- Pathology
Background:
- Primary amyloidosis frequently involves the liver, though typically presents asymptomatically.
- Common hepatic findings include mild alkaline phosphatase elevation and hepatomegaly.
Observation:
- A case of primary amyloidosis presenting with intrahepatic cholestasis in an adult male is described.
- Other potential causes such as viral, drug-induced, alcoholic, and autoimmune hepatitis were ruled out.
Findings:
- Diagnosis was confirmed via liver biopsy demonstrating characteristic Congo red staining.
- The patient was subsequently diagnosed with a monoclonal light chain disorder.
Implications:
- Highlights the importance of considering primary amyloidosis in unexplained intrahepatic cholestasis.
- Underscores the diagnostic value of liver biopsy and Congo red staining in such cases.
- Connects intrahepatic cholestasis to underlying monoclonal gammopathies.
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