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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Paediatric cerebral venous thrombosis

Alper I Dai1

  • 1Department of Pediatrics, Shcool of Medicine, Gaziantep University, Gaziantep, Turkey.

JPMA. the Journal of the Pakistan Medical Association
|December 23, 2006
PubMed

Insights

Cerebral venous thrombosis (CVT) in children is a serious, multifactorial condition increasingly diagnosed due to advanced imaging. Anticoagulant therapy, though debated, appears safe and beneficial for pediatric CVT, even with hemorrhages.

Area of Science:

  • Pediatric Neurology
  • Vascular Neurology
  • Hematology

Background:

  • Cerebral venous thrombosis (CVT) in children is a serious, multifactorial condition.
  • Increasingly diagnosed due to enhanced imaging and clinical awareness.
  • Manifestations can be severe, leading to neurological deficits.

Purpose of the Study:

  • To review the diagnosis, risk factors, and treatment of pediatric CVT.
  • To discuss the role of anticoagulation in pediatric CVT management.

Main Methods:

  • Review of clinical presentations, diagnostic modalities, and treatment options for pediatric CVT.
  • Analysis of the current evidence regarding anticoagulation in children with CVT.

Main Results:

  • CVT presents variably and is associated with diverse risk factors like infection, dehydration, and hematological disorders.
  • CT or MR venography are diagnostic standards; diffusion/perfusion MRI aid in assessing venous congestion.
  • Anticoagulation with heparin is considered safe and potentially beneficial, even in cases with intracranial hemorrhage.

Conclusions:

  • Pediatric CVT requires consideration in various acute neurological presentations.
  • Anticoagulant therapy, typically with heparin followed by oral anticoagulants, is the established treatment approach.
  • Evidence suggests heparin is safe and beneficial for pediatric CVT, including those with hemorrhages.

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