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What do we know about alteration in the osteoblast phenotype with microgravity?

L Vico1

  • 1INSERM, E0366, Bone Biology Laboratory, University of St. Etienne, France. vico@univ-st-etienne.fr

Journal of Musculoskeletal & Neuronal Interactions
|December 23, 2006
PubMed
Summary

No abstract available in PubMed .

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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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