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Updated: Jul 18, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Published on: July 19, 2019

[Lupus profundus and myelopathy].

E Bathelier¹, F Truchot, J Kanitakis

¹Service de Dermatologie, Centre Hospitalier de Valence, Valence.

Annales De Dermatologie Et De Venereologie

|December 23, 2006

Summary

This case report details a rare instance of myelopathy, or spinal cord inflammation, occurring in a patient with lupus profundus. Prompt treatment with corticosteroids and hydroxychloroquine led to a full recovery, highlighting an effective therapeutic approach for this unique complication.

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Last Updated: Jul 18, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

Neurology
Dermatology
Rheumatology

Background:

Lupus profundus, a rare form of lupus erythematosus, typically presents with subcutaneous fat inflammation and is often considered benign.
Systemic involvement in lupus profundus is uncommon, making associated neurological complications exceedingly rare in medical literature.

Observation:

A 29-year-old woman with a history of lupus profundus developed acute myelitis, characterized by spinal cord inflammation at the cervical level.
The patient presented with neurological symptoms including paresthesia, indicative of a medullary lesion, during a flare-up of lupus profundus skin lesions.

Findings:

Magnetic Resonance Imaging (MRI) confirmed acute myelitis at the second cervical vertebra.
The patient experienced a favorable outcome following immediate intravenous methylprednisolone, followed by oral corticosteroids and hydroxychloroquine.

Implications:

This case highlights that lupus profundus, though typically cutaneous, can manifest with severe systemic complications like myelitis.
Early and aggressive corticosteroid therapy, combined with antimalarials, appears effective in managing lupus myelitis, offering a potential treatment paradigm.