Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bleomycin-induced flagellate erythema.

P Duhra1, A Ilchyshyn, R N Das

  • 1Dermatology Department, St Mark's Annexe, Coventry & Warwickshire Hospital, UK.

Clinical and Experimental Dermatology
|May 1, 1991
PubMed
Summary

Bleomycin pleurodesis can cause a specific skin rash called flagellate erythema. This condition involves itchy, whip-like lesions and lymphocytic vasculitis, which resolves over time.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erythroderma (exfoliative dermatitis). Part 2: energy homeostasis and dietetic management strategies.

Clinical and experimental dermatology·2021
Same author

Erythroderma (exfoliative dermatitis). Part 1: underlying causes, clinical presentation and pathogenesis.

Clinical and experimental dermatology·2021
Same author

Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis.

The British journal of dermatology·2019
Same author

Pemphigus foliaceus and acquired haemophilia: a rare but important association with life-threatening consequences.

Clinical and experimental dermatology·2018
Same author

When the cows come home: occupational tinea barbae in a cattle farmer.

The British journal of oral & maxillofacial surgery·2017
Same author

Fine needle aspiration cytology aided categorisation of neuroblastic tumours: a report of two cases.

Cytopathology : official journal of the British Society for Clinical Cytology·2016

Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Bleomycin is a chemotherapy agent used in pleurodesis to treat malignant pleural effusions.
  • Cutaneous side effects of bleomycin are well-documented, but flagellate erythema is a distinct presentation.

Observation:

  • A 56-year-old woman presented with pruritus and a characteristic flagellate erythema following bleomycin pleurodesis.
  • The linear lesions were not induced by scratching, suggesting a mechanism beyond simple dermographism.

Findings:

  • Histopathological examination confirmed lymphocytic vasculitis in the affected skin.
  • The flagellate erythema resolved spontaneously within weeks, leaving post-inflammatory hyperpigmentation for up to six months.

Implications:

  • This case highlights a specific cutaneous reaction to bleomycin, emphasizing the importance of recognizing flagellate erythema.
  • Understanding the pathogenesis, potentially involving vasculitis and scratching, can guide clinical management and patient counseling regarding bleomycin therapy.

Related Experiment Videos