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Vitamin E in renal therapeutic regiments
Mohamed Alaa Thabet1, James C M Chan
1University of Alexandria, Alexandria, Egypt.
Pediatric Nephrology (Berlin, Germany)
|December 23, 2006
Summary
Vitamin E shows potential in managing kidney diseases like IgA nephropathy and FSGS, reducing oxidative stress. However, its overall efficacy and safety, especially at high doses, require further investigation for renal patients.
Area of Science:
- Nephrology
- Nutritional Science
- Clinical Medicine
Background:
- Vitamin E administration in children with IgA nephropathy, FSGS, and type I diabetes suggested potential benefits.
- Oral vitamin E therapy has been shown to reduce endothelial dysfunction, lipid peroxidation, and oxidative stress in chronic kidney failure (CKF) patients.
- Vitamin E-bonded hemodialyzers may decrease atherosclerotic changes, erythropoietin dosage, and muscular cramps in hemodialysis (HD) patients.
Purpose of the Study:
- To review the efficacy and safety of vitamin E in renal therapeutic regimens.
- To discuss the conflicting evidence regarding vitamin E's benefits on cardiovascular and renal outcomes.
- To address concerns about increased all-cause mortality associated with high-dose vitamin E therapy.
Main Methods:
- Review of controlled clinical trials and recent reports on vitamin E in renal patients.
- Analysis of studies investigating oral vitamin E and vitamin E-bonded hemodialyzers.
- Examination of data on vitamin E's impact on oxidative stress, endothelial function, and patient mortality.
Main Results:
- Some studies indicate vitamin E may ameliorate progression in specific pediatric kidney conditions and reduce markers of oxidative stress.
- Controlled trials have failed to consistently demonstrate beneficial cardiovascular and renal outcomes.
- A recent report linked high-dose vitamin E therapy to increased all-cause mortality in adults.
Conclusions:
- The role of vitamin E in renal therapy presents a complex picture with potential localized benefits but uncertain overall efficacy and safety.
- Further research is needed to clarify the risk-benefit profile of vitamin E, particularly high-dose regimens, in patients with kidney disease.
- The conflicting findings necessitate careful consideration of vitamin E use in clinical practice for renal patients.
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