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Characteristics of Streptococcus suis isolated from patients in Japan

Bin Chang1, Akihito Wada, Tadayoshi Ikebe

  • 1Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.

Japanese Journal of Infectious Diseases
|December 26, 2006
PubMed

Insights

Seven cases of Streptococcus suis infection in Japan were analyzed. The study highlights the risks of porcine exposure, particularly with skin injuries, and notes antibiotic resistance patterns in Streptococcus suis (S. suis) serotype 2.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Streptococcus suis is an important zoonotic pathogen.
  • Human infections are often linked to occupational exposure to pigs.

Purpose of the Study:

  • To summarize cases of Streptococcus suis infection in Japan.
  • To analyze clinical manifestations, serotypes, antimicrobial susceptibility, and genetic relatedness of S. suis isolates.

Main Methods:

  • Case series review of seven patients with S. suis infection.
  • Identification of S. suis isolates (Lancefield group D, serotype 2).
  • Antimicrobial susceptibility testing.
  • Multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE).

Main Results:

  • All seven cases involved porcine exposure, with five having hand skin injuries.
  • Clinical presentations included meningitis (5 cases), sepsis (3 cases), and sudden death (1 case).
  • Isolates were susceptible to penicillin G, ampicillin, cefotaxime, and ciprofloxacin, but resistant to erythromycin, clindamycin, and minocycline in varying degrees.
  • MLST identified sequence type (ST) 1 in six isolates and ST28 in one isolate, with similar PFGE patterns for ST1 isolates.

Conclusions:

  • Streptococcus suis serotype 2 poses a significant risk for severe infections, including meningitis and sepsis, following occupational exposure to pigs, especially with skin trauma.
  • The emergence of multidrug-resistant S. suis strains, particularly resistance to erythromycin and clindamycin, is a concern.
  • Genetic analysis indicates a predominant clonal group (ST1) among the studied isolates, suggesting potential for widespread transmission.

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