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The APOBEC-2 crystal structure and functional implications for the deaminase AID

Courtney Prochnow1, Ronda Bransteitter, Michael G Klein

  • 1Molecular and Computational Biology, University of Southern California Los Angeles, California 90089, USA.

Nature
|December 26, 2006
PubMed
Summary

The crystal structure of apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide 2 (APOBEC-2) reveals a unique rod-shaped tetramer. This structure provides insights into how mutations in related proteins, like activation-induced cytidine deaminase, can impair antibody maturation.

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