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Updated: Jul 18, 2026

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix
Published on: September 22, 2014
Cell transplantation for treatment of left-ventricular dysfunction due to ischemic heart failure: from bench to
Aravinda Nanjundappa1, Jaffar Ali Raza, Robert S Dieter
1East Carolina University, Department of Internal Medicine, Division of Cardiology, 600 Moye Blvd, TA 378, Greenville, NC 27834, USA. Dappamd@yahoo.com
Abstract:
Cell transplantation is an innovative technology that involves the implantation of a variety of myogenic and angiogenic cell types. The transplanted cells proliferate and augment left ventricular performance and therein ameliorate the heart failure symptoms. The concept of cell transplantation has followed the footsteps of angiogenesis starting as bench side research. The latter half of the decade saw the transformation of this potential mechanism to a promising therapy for ischemic heart failure. More than 150 patients have been treated with cellular transplantation worldwide. This novel application has the potential to revolutionize alternative therapeutic approaches to management of heart failure.
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