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Ocular complications of autoimmune polyendocrinopathy syndrome type 1

Benjamin Chang1, Donal Brosnahan, Kathryn McCreery

  • 1Department of Ophthalmology, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland. benchang@eircom.net

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|December 26, 2006
PubMed

Insights

Autoimmune polyendocrinopathy syndrome type 1 (APS1) can cause significant ocular complications, primarily severe dry eye and keratoconjunctivitis. These conditions may lead to corneal scarring and vision loss in affected individuals.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Autoimmune Diseases

Background:

  • Autoimmune polyendocrinopathy syndrome type 1 (APS1) is a rare autoimmune disorder.
  • Ocular manifestations of APS1 are not well-documented.
  • Understanding these complications is crucial for timely diagnosis and management.

Purpose of the Study:

  • To investigate and report the spectrum of ocular complications in patients diagnosed with APS1.
  • To highlight the prevalence and severity of eye conditions associated with APS1.

Main Methods:

  • Retrospective study of 17 APS1 patients.
  • Comprehensive ophthalmic examinations including visual acuity, slit-lamp biomicroscopy, tear film evaluation, and fundus examination.
  • Review of clinical manifestations and diagnostic criteria for APS1.

Main Results:

  • 35% of patients exhibited corneal changes.
  • 12% developed severe keratoconjunctivitis requiring intensive treatment.
  • Common findings included reduced tear production (63%), lens opacities (18%), and various refractive errors.

Conclusions:

  • Keratoconjunctivitis associated with dry eye is the most frequent and impactful ocular complication of APS1.
  • Early detection and management are essential to prevent progressive corneal scarring and vision impairment.
Abstract

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