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Updated: Jul 18, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Angiotensin in the kidney: a key to understanding hypertension?
Ulrike Muscha Steckelings1, Rainer Rettig, Thomas Unger
1Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.
Abstract:
A crosstransplantation study between genetically matched angiotensin AT1 receptor knockout and wild-type mice revealed that renal AT1 receptors are required for the development of angiotensin II-induced hypertension (). However, in this experimental setting, hypertension-related left ventricular hypertrophy seemed to depend on blood pressure elevation rather than on the expression of AT1 receptors in the heart.
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