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Simple criterion for selection of flavonoid compounds with anti-HIV activity
Veljko Veljkovic1, Jean-François Mouscadet, Nevena Veljkovic
1Centre for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, PO Box 522, 11001 Belgrade, Serbia. vv@vin.bg.ac.yu
Bioorganic & Medicinal Chemistry Letters
|December 27, 2006
Abstract:
Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criterion to discriminate active from inactive flavonoids that is suitable for rapid in silico screening of flavonoid libraries, and selection and optimization of lead compounds with anti-HIV-1 activity.
