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Updated: Jul 18, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
[Determination of methamphetamine in whole blood by capillary zone electrophoresis after solid phase extraction]
Fei-Jun Gong1, Run-Sheng Zhang
1Shanghai Institute of Criminal Science and Technology, Shanghai 200083, China.
Objective:
To develop a specific CZE method for the determination of methamphetamine in whole blood after solid phase extraction.
Methods:
With the doxapram as internal standard, Oasis column was used to extract drugs from whole blood and the sample was analysized by CZE.
Results:
The method showed excellent linearity and the linear correlation coefficient was 0.994. The relative standard deviation for between-day and within-day were 5.31% and 2.22%, respectively.
Conclusion:
The method is effective, simple, reliable and has been used in the determination of methamphetamine in whole blood.
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