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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Multidisciplinary management of orthopedic patients with sickle cell disease
Sathappan S Sathappan1, Daniel Ginat, Paul E Di Cesare
1Musculoskeletal Research Center NYU Hospital for Joint Diseases, Department of Orthopedic Surgery, New York, NY, USA.
Insights
Pharmacological treatments extend sickle cell disease (SCD) patient lifespan into the sixth decade. Multidisciplinary care for orthopedic SCD patients reduces complications and improves outcomes.
Area of Science:
- Orthopedics
- Hematology
- Genetics
Background:
- Sickle cell disease (SCD) significantly impacts patient lifespan and quality of life.
- Pharmacological advancements extend survival to the sixth decade.
- Hemopoietic cell transplantation offers a curative option but requires technical refinement.
Purpose of the Study:
- To highlight the importance of multidisciplinary management for orthopedic complications in sickle cell disease patients.
- To emphasize the need for improved clinical outcomes in SCD patients undergoing orthopedic surgery.
Main Methods:
- Review of current literature on SCD management and orthopedic interventions.
- Analysis of complication rates and clinical outcomes in SCD patients.
- Discussion of multidisciplinary care models.
Main Results:
- Pharmacological treatment extends patient lifespan.
- Orthopedic procedures are common in SCD patients.
- Multidisciplinary management is associated with decreased complication rates.
Conclusions:
- Integrated, multidisciplinary care is crucial for optimizing orthopedic surgical outcomes in sickle cell disease.
- Improved management strategies can enhance the quality of life for SCD patients requiring orthopedic interventions.
Abstract:
With pharmacological treatment, the lifespan of the patient with sickle cell disease can be extended to the sixth decade. Currently the only curative therapy for sickle cell disease is hemopoietic cell transplantation, which is still undergoing technical refinement. Most patients can be expected to undergo at least one orthopedic surgical procedure in their lifetime. Multidisciplinary management of orthopedic patients with sickle cell disease will decrease the overall complication rates and improve clinical outcomes.
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