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Updated: Jul 18, 2026
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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
[Bladder neurofibroma: case report and bibliographic review]
Pedro Manuel Cabrera Castillo1, Sergio Alonso y Gregorio, José Ramón Cansino Alcaide
1Servicio de Urología, Hospital Universitario la Paz, Madrid, España. manuelcabreracastillo@gmail.com
Archivos Espanoles De Urologia
|December 28, 2006
Summary
Neurofibromatosis is a rare systemic disease affecting the urinary tract, with bladder involvement being uncommon. Diagnosis requires pathological and immunohistochemical studies, and patients need follow-up for potential new lesions.
Area of Science:
- Urology
- Oncology
- Genetics
Background:
- Neurofibromatosis is a rare genetic disorder with a prevalence of 1/3000 newborns, affecting genitourinary tract neurofibromas.
- Genitourinary tract neurofibromas commonly originate from pelvic and bladder nerves, with the bladder being the most frequently impacted organ.
Observation:
- Bladder neurofibromas can manifest as diffuse infiltrative processes or solitary tumors, arising from the bladder wall's nervous ganglia.
- A 45-year-old female presented with voiding symptoms and recurrent urinary tract infections, initially showing a bladder mass and diffuse wall thickening on imaging.
Findings:
- The patient's bladder involvement was the initial clinical presentation, complicating early diagnosis due to the absence of other characteristic neurofibromatosis signs.
- Pathological and immunohistochemical studies confirmed bladder neurofibroma after transurethral resection, with positive staining for S-100 protein and type IV collagen.
Implications:
- This case highlights the importance of pathological diagnosis in suspected bladder neurofibromas, especially when other systemic manifestations are absent.
- Management involves conservative treatment, comprehensive workup for other organ involvement, and long-term patient follow-up for lesion development.
