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Anthelminthic Agents01:15

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Antifeedant C20 diterpene alkaloids.

Azucena González-Coloma1, Matías Reina, Ana Guadaño

  • 1Centro de Ciencias Medioambientales, CSIC, Serrano 115-dpdo., ES-28006 Madrid. azu@ccma.csic.es

Chemistry & Biodiversity
|December 29, 2006
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Summary

C20 diterpenoid alkaloids show insect antifeedant and toxic activity against pests like Spodoptera littoralis and Leptinotarsa decemlineata. Some compounds also exhibit cytotoxic effects and potential for parasite control.

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Area of Science:

  • Natural Product Chemistry
  • Insect Toxicology
  • Parasitology

Background:

  • Diterpenoid alkaloids are plant-derived compounds with diverse biological activities.
  • Understanding their insecticidal and antifeedant properties is crucial for developing sustainable pest management strategies.

Purpose of the Study:

  • To evaluate the insect antifeedant and toxic activity of 21 C20 diterpenoid alkaloids.
  • To investigate the cytotoxic effects of these alkaloids on insect and mammalian cells.
  • To explore their potential in controlling parasitic infections.

Main Methods:

  • Testing 21 C20 diterpenoid alkaloids for antifeedant and toxic effects on Spodoptera littoralis and Leptinotarsa decemlineata.
  • Assessing cytotoxic activity against insect (Sf9) and mammalian (CHO) cell lines.
  • Evaluating the impact of selected compounds on Trypanosoma cruzi mortality.

Main Results:

  • Antifeedant effects were structure- and species-dependent.
  • Rearranged hetisine (20) and 19-oxodihydroatisine (9) were potent antifeedants for L. decemlineata and S. littoralis, respectively.
  • Several compounds displayed selective cytotoxicity against Sf9 cells and increased Trypanosoma cruzi mortality.

Conclusions:

  • C20 diterpenoid alkaloids possess significant insect antifeedant and toxic properties, supporting their role in plant defense.
  • These alkaloids represent a promising avenue for developing novel strategies in pest control and antiparasitic therapies.