Total synthesis of potential antitumor agent, (-)-dictyostatin
P Veeraraghavan Ramachandran1, Amit Srivastava, Debasis Hazra
1Herbert C. Brown Center for Borane Research, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA. chandran@purdue.edu
Organic Letters
|December 29, 2006
Abstract:
[structure: see text] The potential antitumor agent (-)-dictyostatin has been synthesized utilizing Brown crotylboration to achieve eight of the eleven chiral centers. The yield for the 26-step longest sequence is approximately 4%. The C9-C10 coupling is achieved via a stereoselective vinylzincate addition.

